Mar 25, 2026 · Signs and symptoms of cutis laxa include widespread, flaccid skin on various parts of the body, which are most prominent in the face, neck, and groin; as well as signs of premature aging . Mar 25, 2026 · Signs and symptoms of cutis laxa include widespread, flaccid skin on various parts of the body, which are most prominent in the face, neck, and groin; as well as signs of premature aging . The term 'cutis laxa' is Latin for loose or lax skin, and this condition is characterized by skin that is sagging and not stretchy (inelastic). The skin often hangs in loose folds, causing the face and other parts of the body to have a droopy or wrinkled appearance. The term 'cutis laxa' is Latin for loose or lax skin, and this condition is characterized by skin that is sagging and not stretchy (inelastic). The skin often hangs in loose folds, causing the face and other parts of the body to have a droopy or wrinkled appearance. Cutis laxa encompasses a wide variety of disorders. The specific symptoms present, severity and prognosis can vary greatly depending upon the specific type of cutis laxa and the presence and extent of associated symptoms . The specific symptoms and severity can vary even among individuals with the same subtype and even among members of the same fami... Cutis laxa encompasses a wide variety of disorders. The specific symptoms present, severity and prognosis can vary greatly depending upon the specific type of cutis laxa and the presence and extent of associated symptoms . The specific symptoms and severity can vary even among individuals with the same subtype and even among members of the same fami... This disorder is also known as FBLN4-related cutis laxa or autosomal recessive cutis laxa type 1B (ARCL1B). It is a highly variable disorder that range from severe, life-threatening complications early in life (i.e. heart or lung [cardiopulmonary] failure) to cases that are limited to vascular disease and abnormalities of the head and face (craniof...