3 days ago · The meaning of DESPAIR is utter loss of hope. How to use despair in a sentence. the feeling that there is no hope and that you can do nothing to improve a difficult or worrying…. despair synonyms, despair pronunciation, despair translation, English dictionary definition of despair. de·spaired , de·spair·ing , de·spairs 1. To lose all hope: despaired of … Definition of despair noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. See examples of despair used in a sentence. Despair definition: To lose all hope. He turned around in despair, aware that he was not going to survive.