See full safety for more information. Avastin in All Lines Lung (AvaALL) is the first randomized phase 3 study of bevacizumab across multiple lines of treatment beyond progression in non–small cell lung cancer (NSCLC). Blocking VEGF may prevent the growth of new blood vessels that tumors need to … Jul 12, 2019 · The E4599 trial prompted FDA approval of Avastin for the treatment of lung cancer. The trial included 878 patients with locally advanced, metastatic, recurrent, or inoperable NSCLC. May 1, 2026 · Bevacizumab can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are ….